Development and application of advanced techniques for the expression and the purification of recombinant proteins aimed at the characterization of the structure, interactions and dynamics of disease-associated biomacromolecules. Structural data on free or ligand-bound proteins and nucleic acids are primarily collected through solution and solid state NMR spectroscopy.

Research groups: 

• BioDisOrder 

Our research focuses on the underlying biomolecular mechanisms of human diseases. We use biomolecular NMR experiments in solution and in the solid-state and multiscale molecular simulations to investigate protein-protein and protein-membrane interactions at the origins of neurodegenerative disorders, dilated cardiomyopathies and tuberculosis. A special focus is on intrinsically disordered proteins and disordered regions in membrane proteins, for which we develop new integrated approaches tailored to study their structure and dynamics.