Denominazione assente

• Course name: Dottorato di ricerca in Scienza del farmaco
• Course: XXXIX
• Starting from: 2023–2024
• Board committee:

  Coordinator

  MELI Rosaria

  Components

  AMATO Jussara, BORBONE Nicola, BORRELLI Francesca, CIRINO Giuseppe, FATTORUSSO Caterina, GALDIERO Stefania, GALEONE Aldo, GRIECO Paolo, LAVECCHIA Antonio, MARINELLI Luciana, MELI Rosaria, PAGANO Bruno, QUAGLIA Fabiana, RIGANO Daniela, ROSSI Antonietta, RUSSO Roberto, SEPE Valentina, UNGARO Francesca, ZAMPELLA Angela

  Didactic Commission 

  MELI Rosaria (coordinator), GALDIERO Stefania, PAGANO Bruno, RUSSO Roberto, SEPE Valentina

  Admission Commission

  GRIECO Paolo, MELI Rosaria, ZAMPELLA Angela, LAVECCHIA Antonio (first substitute), CIRINO Giuseppe (second substitute)

• Available positions: 32 (di cui 30 con borsa)
• Course length: 3 years
• Course affiliation: Department of Pharmacy
• PhD candidates:
  • Dr. ALBERICO ALESSIA

  Project title: Discovery of potent and selective Direct Antiviral Agents (DAA).

  Tutor: Prof. Vincenzo Summa                                       Cotutor: Prof. Luca Guidotti 

  Funding source: D.M. 117 (Ospedale S. Raffaele)

  • Dr. ALIBERTI CARLA

  Project title: Design, synthesis, structural characterization, and evaluation of the biological properties of therapeutic oligonucleotides based on DNA, RNA and analogs.

  Tutor: Prof. Aldo Galeone                                             Cotutor: Prof. Concetta Giancola

  Funding source: CN3 spoke 6 (RNA Drug development)

  • Dr. ANGELILLO ALESSIA

  Project title: Lipid nanovectors for RNA delivery in central nervous system disorders.

  Tutor: Prof. Giuseppe De Rosa                                      Cotutor: Prof. Rosaria Meli

  Funding source: CN3 spoke 3 (Neurodegeneration)

  • Dr. ARCIUOLO VALENTINA

  Project title: Multimeric G-quadruplex–forming DNA sequences: from characterization to the development of specific binders.

  Tutor: Prof. Bruno Pagano                                            Cotutor: Prof. Maria Teresa Giustiniano

  Funding source: D.M.118 PNRR generici

  • Dr. BAIA VALERIO

  Project title: AMYGING – Imaging multimodale sostenibile di amiloide β

  Tutor: Prof. Margherita Brindisi                               Cotutor: Prof. Vincenzo Summa

  Funding source: Dipartimento di Eccellenza

  • Dr. BILLI CHIARA

  Project title: Design, synthesis, physicochemical characterization and biological evaluations of new drugs for inflammatory-based diseases treatment.

  Tutor: Prof. Maria Grazia Rimoli                               Cotutor: Prof. Stefania Albrizio

  Funding source: Ateneo FFO

  • Dr. BOCCINO IDA

  Project title: Design and Synthesis of Novel Antimicrobial Peptide-based molecules with potentials to tackle bacteria and protozoa.

  Tutor: Prof. Paolo Grieco                                              Cotutor: Prof. Isabel M. Gomez Monterrey

  Funding source: Dipartimento di Eccellenza

  • Dr. CIMMINO WANDA

  Project title: Design and application of point of care testing devices for cancer liquid biopsy.

  Tutor: Prof. Stefano Cinti                                              Cotutor: Dr. Normanno Nicola (IRCCS Pascale)

  Funding source: Convenzione su fondo AIRC

  • Dr. CINQUE PIERFRANCESCO

  Project title: Design and synthesis of molecular hybrids between drugs for dermatological disorders or wound healing and H2S donors.

  Tutor: Prof. Francesco Frecentese                                Cotutor: Dr. Maglione

  Funding source: D.M. 117 (DAMOR Farmaceutici)

  • Dr. CUGUDDA ALESSIA

  Project title: Design, synthesis and characterization of structurally constrained mimetics of the suppressor of cytokine signaling 1 and 3 proteins (SOCS1-SOCS3).

  Tutor: Prof. Daniela Marasco                                   Cotutor: Prof. Lucia Falcigno

  Funding source: Convenzione su fondo AIRC

  • Dr. D'ALESSIO AURORA

  Project title: Neuro-oxidative network in regulating gut barrier function.

  Tutor: Prof. Gabriella Aviello                                    Cotutor: Prof. Giuseppina Mattace Raso

  Funding source: PE 12 Neuroscienze (MNESYS)

  • Dr. D'ANNA PASQUALE

  Project title: Polymeric nanoplatforms for precision delivery of siRNA to solid tumors.

  Tutor: Prof. Claudia Conte                                       Cotutor: Prof. Fabiana Quaglia

  Funding source: CN3 spoke 8 (Platform for DNA-RNA delivery)

  • Dr. DE ROSA MARTINA

  Project title: Development of ligands targeting Adenosine receptor A2A.

  Tutor: Prof. Diego Brancaccio                                       Cotutor: Prof. Alfonso Carotenuto

  Funding source: Ateneo FFO

  • Dr. ESPOSITO CAMILLA

  Project title: Validating acid nucleic-based drugs using in vivo models of colon cancer.

  Tutor: Prof. Giuseppe Cirino                                         Cotutor: Prof. Elisabetta Panza

  Funding source: CN3 spoke 9 (From target to therapy and competence center)

  • Dr. ESPOSITO ERIKA

  Project title: Pharmacokinetic and pharmacodynamic evaluations of RNA-loaded nano-delivery systems for the treatment of pulmonary inflammation.

  Tutor: Prof. Roberta D'Emmanuele di Villabianca      Cotutor: Prof. Raffaella Sorrentino

  Funding source: CN3 spoke 5 (Inflammatory and Infection disease

  • Dr. GARGIULO ERNESTO

  Project title: Sustainable exploitation of plant sources for the identification of new leads of pharmaceutical interest.

  Tutor: Prof. Giuseppina Chianese                      Cotutor: Prof. Orazio Taglialatela Scafati

  Funding source: D.M.118 PNRR generici

  • Dr. IAZZETTI FEDERICA

  Project title: Preclinical development of Ru(III)-based nanoformulations for cancer therapy.

  Tutor: Prof. Carlo Irace                                     Cotutor: Prof. Rita Santamaria

  Funding source: Dipartimento di Eccellenza

  • Dr. LAURENZI VALENTINA

  Project title: Fragment-Based Ligand and Drug Discovery (FBLDD) via marine natural products to fight insulin resistance and inflammatory disorders associated with metabolic syndrome.

  Tutor: Prof. Concetta Imperatore                 Cotutor: Prof. Marialuisa Menna 

  Funding source: D.M.118 PNRR generici

  • Dr. MARINO MARIA ILARIA

  Project title: Elucidating the role of Neuregulin 1 on the neuroinflammatory and behavioral profile in the early-life immune activation model of autism: focus on the brain-gut axis.

  Tutor: Prof. Giuseppina Mattace Raso          Cotutor: Dr. Roberta De Simone (ISS)

  Funding source: Convenzione con Istituto Superiore Sanità (ISS)

  • Dr. MIRAGLIA MARIA

  Project title: TRPV3 in intestinal inflammation and colitis-associated cancer: functional role and drug target.

  Tutor: Dr. Ester Pagano                               Cotutor: Prof. Angelo Antonio Izzo

  Funding source: D.M.118 PNRR generici

  • Dr. MOLARO MARIA CRISTINA

  Project title: Targeting arginase 2 to disrupt the immunosuppressive tumour microenvironment and promote gastric cancer response.

  Tutor: Dr. Federica Sodano                          Cotutor: Prof. Loretta Lazzarato (UNITO)

  Funding source: Convenzione su fondo AIRC

  • Dr. PASCARELLA SILVIA

  Project title: Maternal separation and cerebellum: a study of psychological and neuronal vulnerability to early life stress.

  Tutor: Prof. Maria Concetta Miniaci             Cotutor: Prof. Floriana Volpicelli

  Funding source: PE 12 Neuroscienze (MNESYS)

  • Dr. PEZONE ALBA MARIATERESA

  Project title: Outcome Research as a key in the regulatory process of Gene Therapy: development and validation of a pharmaceutical regulatory framework for the decision-making process.

  Tutor: Prof. Valentina Orlando                       Cotutor: Prof. Enrica Menditto

  Funding source: D.M.118 PA

  • Dr. RIDINÒ MARTINA

  Project title: Design and synthesis of antisense oligonucleotides (ASOs) modified with small molecules.

  Tutor: Prof. Valentina Sepe                          Cotutor: Dr. Federica Moraca

  Funding source: CN3 spoke 4 (Metabolic and Cardiovascular disease)

  • Dr. ROMANO BENEDETTA

  Project title: The role of phosphodiesterases in regulating the function of innate and adaptive immune cells in chronic respiratory diseases.

  Tutor: Prof. Angela Ianaro                           Cotutor: Prof. Giancarlo Tenore

  Funding source: D.M.118 PNRR generici

  • Dr. ROSA MARIA ANGELA

  Project title: Peptide-based nanostructures as delivery tools for active pharmaceutical ingredients.

  Tutor: Dr. Carlo Diaferia                                   Cotutor: Prof. Antonella Accardo

  Funding source: CN3 spoke 8 (Platform for DNA-RNA delivery)

  • Dr. SIMONELLI MARTINA

  Project title: Role of environmental factors on the development of chronic respiratory illnesses.

  Tutor: Prof. Fiorentina Roviezzo                   Cotutor: Dr. Maria Rosaria Vadrucci

  Funding source: D.M.118 PA (ARPAC)

  • Dr. SPINELLI LUCIO

  Project title: Development of a proteomic platform for the characterization of nanoparticles' protein corona.

  Tutor: Prof. Angela Zampella                                   Cotutor: Prof. Valentina Sepe

  Funding source: CN3 spoke 8 (Platform for DNA-RNA delivery)

  • Dr. VERTUCCIO STEFANIA

  Project title: Environmental monitoring of atmospheric particulate (PM2.5) and analysis of characteristic pollutants to which school children residenting in areas of high environmental pressure are exposed and subsequent health impact assessment.

  Tutor: Prof. Elisa Magli                                Cotutor: Dr. Francesca Barone

  Funding source: D.M.118 PA (ARPAC)

  • Dr. VILLANO ERSILIA

  Project title: Inhalable nanoplatforms for RNA delivery in the local treatment of fibrosis and chronic pulmonary inflammation.

  Tutor: Prof. Francesca Ungaro                     Cotutor: Dr. Gabriella Costabile

  Funding source: CN3 spoke 5 (Inflammatory and Infection disease)

  • Dr. VITALE ORIANA

  Project title: Application of computational methods to investigate and optimize the structural stability and the pharmacokinetic properties of lipidbased RNA nanocarrier.

  Tutor: Dr. Federica Moraca                          Cotutor: Prof. Valentina Sepe

  Funding source: CN3 spoke 7 (Biocomputing)

   

• Useful information:

  Results of the assessment of qualifications for applicants to the 39° cycle

  Doctoral Course in Pharmaceutical Sciences –XXXIX Cycle-List of topics for the oral admission

  Topic	Title	Tutor e co-tutor, special fundings
  Topic 1	Bioactive non-viral nanovectors for RNA delivery	Prof. De Rosa Giuseppe CN3-Spoke 3 (Neurodegeneration)
  Topic 2	Design and synthesis of antisense oligonucleotides (ASOs) modified with small molecules	Prof.ssa Sepe Valentina  CN3-Spoke 4 (Metabolic and Cardiovascular disease)
  Topic 3	Design of Modulators of miRNAs Involved in Cardiovascular and Metabolic Disorders through Machine/Deep Learning Techniques and Biosimulations	Prof. Lavecchia Antonio  CN3-Spoke 4 (Metabolic and Cardiovascular disease)
  Topic 4	Inhalable RNA-loaded nanoplatforms for local management of lung fibrosis and chronic inflammation	Proff. Ungaro Francesca-Costabile Gabriella  CN3-Spoke 5 (Inflammatory and Infection disease)
  Topic 5	Pharmacokinetic and pharmacodynamic evaluations of RNA-loaded nano-delivery systems for the treatment of pulmonary inflammation	Prof.ssa D'Emmanuele di Villa Bianca Roberta   CN3-Spoke 5 (Inflammatory and Infection disease)
  Topic 6	Design, synthesis, structural characterization, and evaluation of the biological properties of therapeutic oligonucleotides based on DNA, RNA and analogs	Prof. Galeone Aldo   CN3-Spoke 6 (RNA Drug development)
  Topic 7	Physicochemical investigations on RNA drug based and energetics of their interaction with biomolecular targets	Prof.ssa Giancola Concetta   CN3-Spoke 6 (RNA Drug development)
  Topic 8	Application of computational methods to investigate and optimize the structural stability and the pharmacokinetic properties of lipid-based RNA nanocarriers	Prof.ssa Moraca Federica   CN3-Spoke 7 (Biocomputing)
  Topic 9	Development of chicken ChorioAllantoicMembrane (CAM)-based cancer models to screen trafficking, delivery efficiency, and toxicity of RNA based nanoplatforms	Prof.ssa Russo Annapina   CN3-Spoke 8 (Platform for DNA-RNA delivery)
  Topic 10	Peptide-based nanostructures as delivery tools for active pharmaceutical ingredients	Proff. Diaferia Carlo-Accardo Antonella   CN3-Spoke 8 (Platform for DNA-RNA delivery)
  Topic 11	Polymeric nanoplatforms for precision targeting of siRNA to solid tumors	Prof.ssa Conte Claudia CN3-Spoke 8 (Platform for DNA-RNA delivery)
  Topic 12	Development of a Proteomic Platform to Characterize Nanoparticles Corona Proteins	Prof.ssa Zampella Angela   CN3-Spoke 8 (Platform for DNA-RNA delivery)
  Topic 13	Validating acid nucleic-based drugs using in vitro and in vivo models of cancer	Prof. Cirino Giuseppe CN3-Spoke 9 (From target to therapy and competence center)
  Topic 14	Maternal separation and cerebellum: a study of psychological and neuronal vulnerability to early life stress	Proff. Miniaci Maria Concetta-Perrone Capano Carla   PE (MNESYS)
  Topic 15	Neuronal control of intestinal barrier function	Prof.ssa Aviello Gabriella   PE (MNESYS)
  Topic 16	Design and synthesis of molecular hybrids between drugs for dermatological disorders or wound healing and H2S donors	Prof. Frecentese Francesco   DM217(DAMOR)
  Topic 17	Discovery of potent and selective Direct Antiviral Agents (DAA)	Proff. Summa Vincenzo-Guidotti Luca   DM217 (Ospedale San Raffaele)
  Topic 18	Analysis, composition, exposure and risk assessment of atmospheric particulate matter and characteristic pollutants supporting public organizations	Proff. Perissutti Elisa-Magli Elisa   DM118 Pubblica Amministrazione
  Topic 19	Molecular and cellular mechanisms linking air pollution and lung diseases	Prof.ssa Roviezzo Fiorita   DM118 Pubblica Amministrazione
  Topic 20	Computational approaches of Drug utilization applied to Health Big Data to support health policies for chronicity management	Proff. Menditto Enrica-Orlando Valentina   DM118 Pubblica Amministrazione
  Topic 21	Computational methods of Drug Utilization and Pharmacoeconomics for Healthcare policies in order to develop new regulatory processes for Advanced Therapies	Proff. Orlando Valentina-Menditto Enrica.   DM118 Pubblica Amministrazione
  Topic 22	Mimetics of SOCS proteins as antinflammatory therapeutics in cancer	Proff. Marasco Daniela-Falcigno Lucia Convenzione AIRC
  Topic 23	Portable diagnostics for liquid biopsy application	Prof. Cinti Stefano Convenzione AIRC
  Topic 24	Elucidating the role of Neuregulin 1 on the neuroinflammatory and behavioral profile in the early-life immune activation mouse model of autism: focus on the brain-gut axis	Proff. Mattace Raso Giuseppina-De Simone Roberta   Convenzione ISS
  Topic 25	Targeting arginase 2 to disrupt the immunosuppressive tumour microenvironment and promote gastric cancer response	Dott.ssa Sodano Federica   Convenzione AIRC
  Topic 26	Preclinical development of Ru-based nanoformulation for cancer therapy	Proff. Irace Carlo-Santamaria Rita
  Topic 27	New RNA-based therapeutic strategies to overcome chemoresistance in colorectal cancer	Proff. Russo Giulia-Russo Annapina
  Topic 28	The role of phosphodiesterases in regulating the function of innate and adaptive immune cells in chronic respiratory diseases	Proff. Ianaro Angela-Tenore Giancarlo
  Topic 29	TRPV3 in intestinal inflammation and colitis-associated cancer: functional role and pharmacological targeting	Proff. Pagano Ester-Izzo Angelo
  Topic 30	Proposed Research Theme: IL-17A/IL-17RA axis in the association of autoimmune diseases with cardiovascular complications	Proff. Maione Francesco-Cirino Giuseppe
  Topic 31	Metabolites from Cannabis – green expansion of chemical and biological space	Proff. Chianese Giuseppina-Taglialatela Orazio
  Topic 32	α-synuclein/hDAT interaction: a new target against Parkinson's Disease	Proff. De Simone Alfonso-Stornaiuolo Mariano
  Topic 33	Design and synthesis of nature-inspired compounds as potential anti-inflammatory/anticancer agents	Proff. De Marino Simona-D'Auria Valeria
  Topic 34	Fragment-Based Ligand and Drug Discovery (FBLDD) via marine natural products to fight insulin resistance and inflammatory disorders associated with metabolic syndrome	Proff. Imperatore Concetta-Menna Marialuisa
  Topic 35	Design, synthesis, physicochemical characterization, and biological evaluations of new drugs for inflammatory-based disease treatmen	Proff. Rimoli Maria Grazia- Albrizio Stefania
  Topic 36	Antimicrobial peptides as promising agents able to counteract the antibiotic resistance of bacteria and protozoa	Proff. Grieco Paolo-Isabel Gomez Monterrey
  Topic 37	Holistically sustainable multi-modal β-amyloid imaging	Proff. Brindisi Margherita-Summa Vincenza
  Topic 38	Development of Ligands targeting Adenosine receptor A2A	Proff. Brancaccio Diego-Carotenuto Alfonso
  Topic 39	Development of supramolecular peptide nanosystems for the delivery of new bioinorganic drugs	Proff. Tesauro Diego-Morelli Giancarlo
  Topic 40	Multimeric G-quadruplex–forming DNA sequences: from characterization to the development of specific binders	Proff. Pagano Bruno-Giustiniano Mariateresa
  Topic 41	Emerging toxins in italian seas and risks for human health	Proff. Dell'Aversano Carmela- Varra Michela