drug delivery technologies
The research activity is focused on the design, production and characterization of Drug Delivery Systems (DDS) for bioactive molecules to be applied in the pharmaceutical, biomedical and nutraceutical fields. Different polymeric and lipidic nano/microcarriers, polymeric films and hydrogels are under development to optimize the pharmacokinetics, the therapeutic efficacy and the toxicological profile of small drugs, natural substances and biotherapeutics. Further interest is devoted to the investigation of the relationship between the macroscopic features and the molecular structure of biomaterials through the analysis of their rheological, thermodynamic and transport properties. DDS are preferably produced through scalable technologies. A preGMP facility is available to produce lab-validated DDS prototypes.
Research groups:
- DeliTECH
- Polymeric nanoplatforms for combined and light-activated cancer therapies;
- Polymer-based inhalable nano- and microcarriers for the local treatment of severe lung diseases;
- Polymeric and lipid-based platforms for oromucosal delivery;
- Multifunctional polymeric platforms for skin wound healing.
Research Team:
- BioNanoMed
Development of advanced formulations for the delivery of bioactive molecules, including RNA (mRNA, miRNA or siRNA) or molecules from nature. The strategies mainly involve non-viral lipid or polymeric nanocarriers, as well as hydrogels and polymeric films. These technologies are used in crossing biological barriers (blood-brain barrier, skin, etc.), targeting specific tissues or cells, solving biopharmaceutical drug issues, or in the drug repositioning.
Research Team:
- Radio-Tech