Research groups
- MedChem
The group exploit many different skills, including computer aided drug design, synthesis and biophysical characterization, for the development of novel bioactive compounds (organic and/or peptide) targeting biomolecules involved in the pathogenesis and in the progression of many diseases including neurodegenerative diseases and cancer.
- PharmChem
- HSDD
- SynBioLab
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LiRiSyM
The LiRiSyM group (Ligands of Receptors involved in Metabolic Syndrome) is involved in the design and synthesis of steroidal bile acid derivatives as selective and/or dual modulators of bile acid receptors, FXR and GPBAR1 - Our research activity is focused towards the design and the synthesis of new leads as promising therapeutic strategy in metabolic syndrome. The research line focused on the synthesis of bile acid derivatives is part of a research agreement with BAR Pharmaceuticals. Recently, the research has also shifted towards the synthesis of steroidal and aromatic compounds with the aim of obtaining multi-target derivatives, such as for example dual agonists of GPBAR1 and GPR119 receptors. New ligands of these receptors can be used in the treatment of obesity and diabetes.
- SIDG
The research activity is aimed at the design and synthesis of new antimalarial lead compounds presenting as the pharmacophoric moieties kinonic structures inspired by bioactive natural compounds. This research utilizes the know-how in the field of organic and computational chemistry of two research units at the University of Naples Federico II (SIDG and NeaCADD). The SIDG research group is already actively involved in the field of malaria research, and since 2007 it represents the University of Naples Federico II in the "Centro Interuniversitario per la Ricerca sulla Malaria" (CIRM) within the Italian Malaria Network (IMN). In addition, this research is based on the collaboration of a Spanish research group led by Prof. Doménech-Carbò (University of Valencia, Spain) who, using an innovative voltammetric technique on solid phase microparticles, provides important information on the electrochemical response of quinones in order to evaluate the ability of these compounds to react with the eme and the reactive oxygen species (ROS).